Drug interactions
Calcium carbonate + Cefpodoxime
Severity: Moderate
Calcium carbonate and Cefpodoxime: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefpodoxime proxetil needs gastric acid for dissolution, and antacids lower its absorption. This may reduce antibacterial effectiveness.
What this interaction means in plain words
Calcium carbonate and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Cefpodoxime belongs to Anti Bacterial.
Why it happens
Raised gastric pH decreases dissolution and absorption of cefpodoxime proxetil.
What to do
Separate cefpodoxime from calcium carbonate by about 2 hours and take it with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
- Cefpodoxime + Didanosine Moderate
Frequently asked questions
Can I take Calcium carbonate with Cefpodoxime?
MediHelp rates the interaction as moderate. Calcium carbonate and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefpodoxime proxetil needs gastric acid for dissolution, and antacids lower its absorption. This may reduce antibacterial effectiveness.
How serious is the interaction between Calcium carbonate and Cefpodoxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate cefpodoxime from calcium carbonate by about 2 hours and take it with food.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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