Drug interactions
Calcium + Cefpodoxime
Severity: Moderate
Calcium and Cefpodoxime: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefpodoxime proxetil absorption is reduced when gastric acidity is lowered by antacids such as calcium carbonate. Reduced levels may lessen antibacterial efficacy.
What this interaction means in plain words
Calcium and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Cefpodoxime belongs to Anti Bacterial.
Why it happens
Raised gastric pH reduces dissolution and absorption of cefpodoxime proxetil.
What to do
Separate cefpodoxime from calcium carbonate by at least 2 hours, and take cefpodoxime with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
- Cefpodoxime + Didanosine Moderate
Frequently asked questions
Can I take Calcium with Cefpodoxime?
MediHelp rates the interaction as moderate. Calcium and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefpodoxime proxetil absorption is reduced when gastric acidity is lowered by antacids such as calcium carbonate. Reduced levels may lessen antibacterial efficacy.
How serious is the interaction between Calcium and Cefpodoxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate cefpodoxime from calcium carbonate by at least 2 hours, and take cefpodoxime with food.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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