Drug interactions
Cefpodoxime + Cimetidine
Severity: Moderate
Cefpodoxime and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
H2 blockers lower the oral absorption of cefpodoxime proxetil. Lower antibiotic levels may reduce efficacy.
What this interaction means in plain words
Cefpodoxime and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces dissolution and absorption of cefpodoxime proxetil.
What to do
Prefer an alternative antibiotic or stop the acid suppressant if possible. Take cefpodoxime with food to improve absorption and monitor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Didanosine Moderate
Frequently asked questions
Can I take Cefpodoxime with Cimetidine?
MediHelp rates the interaction as moderate. Cefpodoxime and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. H2 blockers lower the oral absorption of cefpodoxime proxetil. Lower antibiotic levels may reduce efficacy.
How serious is the interaction between Cefpodoxime and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic or stop the acid suppressant if possible. Take cefpodoxime with food to improve absorption and monitor response.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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