Drug interactions
Cefpodoxime + Rabeprazole
Severity: Moderate
Cefpodoxime and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefpodoxime proxetil needs gastric acidity for optimal dissolution and absorption, so rabeprazole can lower its bioavailability. This may reduce antibacterial efficacy.
What this interaction means in plain words
Cefpodoxime and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH decreases dissolution and absorption of cefpodoxime proxetil.
What to do
Avoid the combination where possible or choose an alternative antibiotic such as one not dependent on gastric acid; taking cefpodoxime with food partly improves absorption.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Frequently asked questions
Can I take Cefpodoxime with Rabeprazole?
MediHelp rates the interaction as moderate. Cefpodoxime and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefpodoxime proxetil needs gastric acidity for optimal dissolution and absorption, so rabeprazole can lower its bioavailability. This may reduce antibacterial efficacy.
How serious is the interaction between Cefpodoxime and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible or choose an alternative antibiotic such as one not dependent on gastric acid; taking cefpodoxime with food partly improves absorption.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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