Drug interactions
Cefprozil + Streptomycin
Severity: Moderate
Cefprozil and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptomycin is nephrotoxic and ototoxic, particularly to the vestibular system, and cephalosporins may add to renal injury in some reports. Reduced renal clearance increases streptomycin accumulation and the risk of irreversible damage.
What this interaction means in plain words
Cefprozil and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefprozil belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with decreased renal clearance raising aminoglycoside exposure.
What to do
Monitor serum creatinine and assess vestibular and hearing function during therapy. Adjust the streptomycin dose to renal function and limit duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Other interactions of Streptomycin
Frequently asked questions
Can I take Cefprozil with Streptomycin?
MediHelp rates the interaction as moderate. Cefprozil and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptomycin is nephrotoxic and ototoxic, particularly to the vestibular system, and cephalosporins may add to renal injury in some reports. Reduced renal clearance increases streptomycin accumulation and the risk of irreversible damage.
How serious is the interaction between Cefprozil and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and assess vestibular and hearing function during therapy. Adjust the streptomycin dose to renal function and limit duration.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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