Drug interactions
Cefprozil + Tobramycin
Severity: Moderate
Cefprozil and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobramycin can damage the kidneys and inner ear, and concurrent cephalosporin use has been associated with additional renal injury in some reports. Impaired renal function raises tobramycin levels and the risk of ototoxicity.
What this interaction means in plain words
Cefprozil and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefprozil belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with reduced renal clearance increasing aminoglycoside exposure.
What to do
Monitor renal function and tobramycin concentrations, and ask about hearing or balance changes. Adjust the tobramycin dose to levels and creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Cefprozil with Tobramycin?
MediHelp rates the interaction as moderate. Cefprozil and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tobramycin can damage the kidneys and inner ear, and concurrent cephalosporin use has been associated with additional renal injury in some reports. Impaired renal function raises tobramycin levels and the risk of ototoxicity.
How serious is the interaction between Cefprozil and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and tobramycin concentrations, and ask about hearing or balance changes. Adjust the tobramycin dose to levels and creatinine clearance.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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