Drug interactions
Ceftaroline fosamil + Kanamycin
Severity: Moderate
Ceftaroline fosamil and Kanamycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Kanamycin can injure the kidneys and inner ear, and both drugs are eliminated renally. Adding ceftaroline may contribute modestly to renal stress, and any fall in kidney function would raise kanamycin exposure and ototoxicity risk.
What this interaction means in plain words
Ceftaroline fosamil and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive nephrotoxicity with reduced renal clearance of both drugs if kidney injury develops.
What to do
Monitor serum creatinine regularly and adjust ceftaroline dose to renal function. Check kanamycin levels where available and watch for hearing or balance changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftaroline fosamil
Frequently asked questions
Can I take Ceftaroline fosamil with Kanamycin?
MediHelp rates the interaction as moderate. Ceftaroline fosamil and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Kanamycin can injure the kidneys and inner ear, and both drugs are eliminated renally. Adding ceftaroline may contribute modestly to renal stress, and any fall in kidney function would raise kanamycin exposure and ototoxicity risk.
How serious is the interaction between Ceftaroline fosamil and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine regularly and adjust ceftaroline dose to renal function. Check kanamycin levels where available and watch for hearing or balance changes.
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Amikacin, Cholera vaccine, Gentamicin. The full list is on the Ceftaroline fosamil page.
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