Drug interactions
Ceftaroline fosamil + Plazomicin
Severity: Moderate
Ceftaroline fosamil and Plazomicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin is an aminoglycoside with known nephrotoxicity, ototoxicity and neuromuscular blockade risk, and both drugs are renally eliminated. Adding ceftaroline may contribute to renal stress, and reduced kidney function would increase plazomicin exposure.
What this interaction means in plain words
Ceftaroline fosamil and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftaroline fosamil belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity with reduced renal clearance of both drugs if kidney injury occurs.
What to do
Monitor serum creatinine and plazomicin concentrations per labeling, and adjust doses to renal function. Assess hearing and balance during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceftaroline fosamil and Plazomicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ceftaroline fosamil
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Ceftaroline fosamil with Plazomicin?
MediHelp rates the interaction as moderate. Ceftaroline fosamil and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is an aminoglycoside with known nephrotoxicity, ototoxicity and neuromuscular blockade risk, and both drugs are renally eliminated. Adding ceftaroline may contribute to renal stress, and reduced kidney function would increase plazomicin exposure.
How serious is the interaction between Ceftaroline fosamil and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations per labeling, and adjust doses to renal function. Assess hearing and balance during therapy.
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Amikacin, Cholera vaccine, Gentamicin. The full list is on the Ceftaroline fosamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
