Drug interactions
Ceftaroline fosamil + Microbiota
Severity: Moderate
Ceftaroline fosamil and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota products contain live bacterial spores intended to recolonize the gut. A systemic cephalosporin that is partly excreted into the gut lumen may reduce the viability of the spores and blunt the preventive effect against recurrent Clostridioides difficile infection.
What this interaction means in plain words
Ceftaroline fosamil and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The antibacterial activity of the cephalosporin can reduce the viability of the live bacterial spores in the product.
What to do
Finish the antibiotic course before starting oral microbiota therapy, and keep the labeled interval after the last antibiotic dose (typically 2 to 4 days).
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftaroline fosamil
Frequently asked questions
Can I take Ceftaroline fosamil with Microbiota?
MediHelp rates the interaction as moderate. Ceftaroline fosamil and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota products contain live bacterial spores intended to recolonize the gut. A systemic cephalosporin that is partly excreted into the gut lumen may reduce the viability of the spores and blunt the preventive effect against recurrent Clostridioides difficile infection.
How serious is the interaction between Ceftaroline fosamil and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Finish the antibiotic course before starting oral microbiota therapy, and keep the labeled interval after the last antibiotic dose (typically 2 to 4 days).
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Amikacin, Cholera vaccine, Gentamicin. The full list is on the Ceftaroline fosamil page.
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