Drug interactions
Amikacin + Ceftaroline fosamil
Severity: Moderate
Amikacin and Ceftaroline fosamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amikacin is nephrotoxic and ototoxic, and concurrent cephalosporin use has been associated with additional renal injury in some reports. Ceftaroline has little direct nephrotoxicity, so the added risk is modest but matters in renal impairment.
What this interaction means in plain words
Amikacin and Ceftaroline fosamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Ceftaroline fosamil belongs to Anti Bacterial.
Why it happens
Additive renal tubular stress, with reduced renal function increasing aminoglycoside accumulation.
What to do
Monitor serum creatinine and amikacin levels and adjust doses to renal function. Limit combined duration and watch for auditory or vestibular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amikacin and Ceftaroline fosamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ceftaroline fosamil
- Ceftaroline fosamil + Cholera vaccine Moderate
- Ceftaroline fosamil + Gentamicin Moderate
- Ceftaroline fosamil + Kanamycin Moderate
- Ceftaroline fosamil + Microbiota Moderate
- Ceftaroline fosamil + Plazomicin Moderate
- Ceftaroline fosamil + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Amikacin
- Amikacin + Cidofovir Contraindicated
- Adefovir + Amikacin Major
- Amikacin + Amphotericin b Major
- Amikacin + Amphotericin b deoxycholate Major
- Amikacin + Atracurium Major
- Amikacin + Bacitracin Major
Frequently asked questions
Can I take Amikacin with Ceftaroline fosamil?
MediHelp rates the interaction as moderate. Amikacin and Ceftaroline fosamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic and ototoxic, and concurrent cephalosporin use has been associated with additional renal injury in some reports. Ceftaroline has little direct nephrotoxicity, so the added risk is modest but matters in renal impairment.
How serious is the interaction between Amikacin and Ceftaroline fosamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels and adjust doses to renal function. Limit combined duration and watch for auditory or vestibular symptoms.
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Cholera vaccine, Gentamicin, Kanamycin. The full list is on the Ceftaroline fosamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
