Drug interactions
Ceftazidime + Dexamethasone-tobramycin
Severity: Moderate
Ceftazidime and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftazidime combined with an aminoglycoside is a common regimen, and reports suggest a possible small increase in kidney injury. Aminoglycoside nephrotoxicity and ototoxicity are the main clinical concern.
What this interaction means in plain words
Ceftazidime and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftazidime belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity; the mechanism is not firmly established.
What to do
Monitor serum creatinine and urine output, and use tobramycin drug-level monitoring. Reduce dose or interval if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Ceftazidime
- Amikacin + Ceftazidime Moderate
- Ceftazidime + Cholera vaccine Moderate
- Ceftazidime + Gentamicin Moderate
- Ceftazidime + Kanamycin Moderate
- Ceftazidime + Microbiota Moderate
- Ceftazidime + Plazomicin Moderate
Frequently asked questions
Can I take Ceftazidime with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Ceftazidime and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftazidime combined with an aminoglycoside is a common regimen, and reports suggest a possible small increase in kidney injury. Aminoglycoside nephrotoxicity and ototoxicity are the main clinical concern.
How serious is the interaction between Ceftazidime and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output, and use tobramycin drug-level monitoring. Reduce dose or interval if renal function declines.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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