Drug interactions
amikacin + ceftazidime
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive nephrotoxicity when coadministered; risk increased with high doses, prolonged therapy, or renal impairment.
Mechanism of action
Pharmacodynamic additive nephrotoxicity; both agents can injure renal tubules, especially with elevated exposures and impaired clearance.
Clinical management
Use only if benefit outweighs risk. Baseline and at least twice-weekly SCr/BUN and urine output; adjust doses for renal function; perform amikacin TDM (peaks/troughs) and adjust accordingly; avoid additional nephrotoxins.
Drug reference
Frequently asked questions
Can I take amikacin with ceftazidime?
The interaction is rated: Moderate. Additive nephrotoxicity when coadministered; risk increased with high doses, prolonged therapy, or renal impairment.
How serious is the interaction between amikacin and ceftazidime?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between amikacin and ceftazidime managed?
Use only if benefit outweighs risk. Baseline and at least twice-weekly SCr/BUN and urine output; adjust doses for renal function; perform amikacin TDM (peaks/troughs) and adjust accordingly; avoid additional nephrotoxins.
Why do amikacin and ceftazidime interact?
Pharmacodynamic additive nephrotoxicity; both agents can injure renal tubules, especially with elevated exposures and impaired clearance.
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