Drug interactions
Ceftazidime + Plazomicin
Severity: Moderate
Ceftazidime and Plazomicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin is nephrotoxic, ototoxic and can cause neuromuscular blockade, and concurrent use with ceftazidime may add to renal stress. The combination is sometimes used deliberately for resistant Gram-negative infection, but kidney function can deteriorate.
What this interaction means in plain words
Ceftazidime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftazidime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic potential, with impaired renal function raising plazomicin exposure and ototoxic risk.
What to do
Monitor serum creatinine frequently and use plazomicin therapeutic drug monitoring if available. Adjust doses to renal function and watch for hearing or balance changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftazidime
- Amikacin + Ceftazidime Moderate
- Ceftazidime + Cholera vaccine Moderate
- Ceftazidime + Dexamethasone-tobramycin Moderate
- Ceftazidime + Gentamicin Moderate
- Ceftazidime + Kanamycin Moderate
- Ceftazidime + Microbiota Moderate
Other interactions of Plazomicin
- Cefaclor + Plazomicin Moderate
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
Frequently asked questions
Can I take Ceftazidime with Plazomicin?
MediHelp rates the interaction as moderate. Ceftazidime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is nephrotoxic, ototoxic and can cause neuromuscular blockade, and concurrent use with ceftazidime may add to renal stress. The combination is sometimes used deliberately for resistant Gram-negative infection, but kidney function can deteriorate.
How serious is the interaction between Ceftazidime and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine frequently and use plazomicin therapeutic drug monitoring if available. Adjust doses to renal function and watch for hearing or balance changes.
What other medicines interact with Ceftazidime?
MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.
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