Drug interactions
Ceftibuten + Mefenamic acid
Severity: Minor
Ceftibuten and Mefenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftibuten is renally secreted as an organic anion and may compete with mefenamic acid for tubular elimination. Any increase in NSAID exposure is likely small.
What this interaction means in plain words
Ceftibuten and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated renal tubular secretion.
What to do
No routine adjustment is needed; monitor for NSAID adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Ceftibuten with Mefenamic acid?
MediHelp rates the interaction as minor. Ceftibuten and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftibuten is renally secreted as an organic anion and may compete with mefenamic acid for tubular elimination. Any increase in NSAID exposure is likely small.
How serious is the interaction between Ceftibuten and Mefenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for NSAID adverse effects in patients with renal impairment.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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