Drug interactions
Ceftizoxime + Gentamicin
Severity: Minor
Ceftizoxime and Gentamicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins given with aminoglycosides have occasionally been linked to additional kidney injury, though evidence for ceftizoxime is limited. Risk is greatest in patients with pre-existing renal disease.
What this interaction means in plain words
Ceftizoxime and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive proximal tubular injury; mechanism not established.
What to do
Monitor serum creatinine and gentamicin levels, and adjust doses for renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Ceftizoxime with Gentamicin?
MediHelp rates the interaction as minor. Ceftizoxime and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalosporins given with aminoglycosides have occasionally been linked to additional kidney injury, though evidence for ceftizoxime is limited. Risk is greatest in patients with pre-existing renal disease.
How serious is the interaction between Ceftizoxime and Gentamicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, and adjust doses for renal function.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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