Drug interactions
Ceftobiprole medocaril + Lovastatin
Severity: Moderate
Ceftobiprole medocaril and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro and may raise lovastatin exposure. Higher statin levels could increase the risk of myopathy.
What this interaction means in plain words
Ceftobiprole medocaril and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP-mediated hepatic uptake of lovastatin acid.
What to do
Monitor for muscle symptoms during the short course of ceftobiprole. Consider temporarily holding lovastatin if the patient is at high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Ceftobiprole medocaril with Lovastatin?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro and may raise lovastatin exposure. Higher statin levels could increase the risk of myopathy.
How serious is the interaction between Ceftobiprole medocaril and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms during the short course of ceftobiprole. Consider temporarily holding lovastatin if the patient is at high risk.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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