Drug interactions
Ceftobiprole medocaril + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Ceftobiprole medocaril and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro, and voxilaprevir is a substrate of these transporters. Exposure to voxilaprevir may therefore rise, with possible liver enzyme elevations. The clinical significance is uncertain.
What this interaction means in plain words
Ceftobiprole medocaril and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ceftobiprole inhibits hepatic OATP1B1/1B3 uptake of voxilaprevir.
What to do
Consider delaying HCV therapy or using an alternative antibiotic if feasible. If coadministered, monitor liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Ceftobiprole medocaril with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro, and voxilaprevir is a substrate of these transporters. Exposure to voxilaprevir may therefore rise, with possible liver enzyme elevations. The clinical significance is uncertain.
How serious is the interaction between Ceftobiprole medocaril and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider delaying HCV therapy or using an alternative antibiotic if feasible. If coadministered, monitor liver enzymes.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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