Drug interactions
Ceftolozane / tazobactam + Gentamicin
Severity: Minor
Ceftolozane / tazobactam and Gentamicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no firmly established interaction increasing gentamicin toxicity with ceftolozane/tazobactam. Both are renally cleared, so impaired kidney function can raise exposure to each drug.
What this interaction means in plain words
Ceftolozane / tazobactam and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive renal stress; no established direct mechanism.
What to do
Monitor serum creatinine and gentamicin levels, and adjust doses for renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Ceftolozane / tazobactam with Gentamicin?
MediHelp rates the interaction as minor. Ceftolozane / tazobactam and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no firmly established interaction increasing gentamicin toxicity with ceftolozane/tazobactam. Both are renally cleared, so impaired kidney function can raise exposure to each drug.
How serious is the interaction between Ceftolozane / tazobactam and Gentamicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, and adjust doses for renal function.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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