Drug interactions
Ceftriaxone + Probenecid
Severity: Minor
Ceftriaxone and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftriaxone is eliminated by both biliary and renal routes. Probenecid has a limited effect on its exposure, and the interaction is generally not clinically significant.
What this interaction means in plain words
Ceftriaxone and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceftriaxone belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid may modestly reduce tubular secretion of ceftriaxone, but the drug has dual elimination so the effect is small.
What to do
No dose adjustment is required. No special monitoring is needed in patients with normal renal and hepatic function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Frequently asked questions
Can I take Ceftriaxone with Probenecid?
MediHelp rates the interaction as minor. Ceftriaxone and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftriaxone is eliminated by both biliary and renal routes. Probenecid has a limited effect on its exposure, and the interaction is generally not clinically significant.
How serious is the interaction between Ceftriaxone and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. No special monitoring is needed in patients with normal renal and hepatic function.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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