Drug interactions
Ceftriaxone + Voclosporin
Severity: Minor
Ceftriaxone and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, while ceftriaxone only rarely affects the kidney. The combination could add modestly to renal risk, mainly in patients with existing renal impairment.
What this interaction means in plain words
Ceftriaxone and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceftriaxone belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Possible additive nephrotoxicity; the contribution of ceftriaxone is small and not well established.
What to do
Monitor serum creatinine and eGFR during concurrent therapy and follow voclosporin dose-reduction guidance if renal function falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ceftriaxone with Voclosporin?
MediHelp rates the interaction as minor. Ceftriaxone and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin is a calcineurin inhibitor with dose-related nephrotoxicity, while ceftriaxone only rarely affects the kidney. The combination could add modestly to renal risk, mainly in patients with existing renal impairment.
How serious is the interaction between Ceftriaxone and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR during concurrent therapy and follow voclosporin dose-reduction guidance if renal function falls.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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