Drug interactions
Cefuroxime + Voclosporin
Severity: Minor
Cefuroxime and Voclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, is nephrotoxic. Cefuroxime has little intrinsic nephrotoxicity, so any additive kidney risk is small, but renal function matters in lupus nephritis patients receiving voclosporin.
What this interaction means in plain words
Cefuroxime and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefuroxime belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Possible additive renal effects; cefuroxime has minimal nephrotoxic potential, so the interaction is largely theoretical.
What to do
Monitor serum creatinine and eGFR as already required for voclosporin therapy. Adjust cefuroxime dose only if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefuroxime and Voclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Cefuroxime with Voclosporin?
MediHelp rates the interaction as minor. Cefuroxime and Voclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voclosporin, a calcineurin inhibitor, is nephrotoxic. Cefuroxime has little intrinsic nephrotoxicity, so any additive kidney risk is small, but renal function matters in lupus nephritis patients receiving voclosporin.
How serious is the interaction between Cefuroxime and Voclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR as already required for voclosporin therapy. Adjust cefuroxime dose only if renal function declines.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Amikacin, Bcg vaccine live. The full list is on the Cefuroxime page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
