Drug interactions
Celecoxib + Chlorpropamide
Severity: Moderate
Celecoxib and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is metabolized by CYP2C9, as is chlorpropamide to a degree, and NSAIDs may potentiate sulfonylurea hypoglycemia. Hypoglycemia is possible, particularly in older patients or those with renal impairment, though the clinical magnitude with celecoxib is modest.
What this interaction means in plain words
Celecoxib and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Chlorpropamide belongs to Endocrine.
Why it happens
Possible competition for CYP2C9 metabolism and protein binding, and reduced renal clearance of chlorpropamide, may raise sulfonylurea exposure.
What to do
Monitor blood glucose when starting or stopping celecoxib and reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Celecoxib with Chlorpropamide?
MediHelp rates the interaction as moderate. Celecoxib and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib is metabolized by CYP2C9, as is chlorpropamide to a degree, and NSAIDs may potentiate sulfonylurea hypoglycemia. Hypoglycemia is possible, particularly in older patients or those with renal impairment, though the clinical magnitude with celecoxib is modest.
How serious is the interaction between Celecoxib and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping celecoxib and reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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