Drug interactions
Celecoxib + Chlorthalidone
Severity: Moderate
Celecoxib and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can blunt the antihypertensive and diuretic effects of chlorthalidone and add to the risk of renal impairment, particularly in volume-depleted or older patients.
What this interaction means in plain words
Celecoxib and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Chlorthalidone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduces renal perfusion.
What to do
Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Adjust diuretic dose if response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Celecoxib with Chlorthalidone?
MediHelp rates the interaction as moderate. Celecoxib and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can blunt the antihypertensive and diuretic effects of chlorthalidone and add to the risk of renal impairment, particularly in volume-depleted or older patients.
How serious is the interaction between Celecoxib and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Adjust diuretic dose if response is reduced.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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