Drug interactions
Celecoxib + Dabigatran etexilate
Severity: Moderate
Celecoxib and Dabigatran etexilate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as celecoxib increase bleeding risk when taken with anticoagulants, mainly through gastrointestinal mucosal injury. Celecoxib has less effect on platelets than nonselective NSAIDs, but gastrointestinal and renal risks remain, and renal impairment can raise dabigatran levels.
What this interaction means in plain words
Celecoxib and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Dabigatran etexilate belongs to Cardiovascular.
Why it happens
Additive bleeding risk from anticoagulation plus NSAID-related mucosal injury, with possible NSAID-related reduction in renal function lowering dabigatran clearance.
What to do
Use the lowest effective celecoxib dose for the shortest time and consider gastroprotection. Monitor for bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Dabigatran etexilate?
MediHelp rates the interaction as moderate. Celecoxib and Dabigatran etexilate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as celecoxib increase bleeding risk when taken with anticoagulants, mainly through gastrointestinal mucosal injury. Celecoxib has less effect on platelets than nonselective NSAIDs, but gastrointestinal and renal risks remain, and renal impairment can raise dabigatran levels.
How serious is the interaction between Celecoxib and Dabigatran etexilate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective celecoxib dose for the shortest time and consider gastroprotection. Monitor for bleeding and renal function.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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