Drug interactions
Celecoxib + Daprodustat
Severity: Minor
Celecoxib and Daprodustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daprodustat is metabolized mainly by CYP2C8, and inhibitors of this enzyme raise its exposure. Celecoxib's inhibitory effect on CYP2C8 is not well established, so the effect is uncertain, but increased daprodustat exposure could raise the risk of thrombotic events and hypertension.
What this interaction means in plain words
Celecoxib and Daprodustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Daprodustat belongs to Endocrine.
Why it happens
Possible CYP2C8 inhibition by celecoxib reducing daprodustat metabolism; not well established.
What to do
Monitor hemoglobin and blood pressure when starting or stopping celecoxib, and adjust the daprodustat dose to hemoglobin response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Celecoxib with Daprodustat?
MediHelp rates the interaction as minor. Celecoxib and Daprodustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daprodustat is metabolized mainly by CYP2C8, and inhibitors of this enzyme raise its exposure. Celecoxib's inhibitory effect on CYP2C8 is not well established, so the effect is uncertain, but increased daprodustat exposure could raise the risk of thrombotic events and hypertension.
How serious is the interaction between Celecoxib and Daprodustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and blood pressure when starting or stopping celecoxib, and adjust the daprodustat dose to hemoglobin response.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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