Drug interactions
Celecoxib + Deflazacort
Severity: Moderate
Celecoxib and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both an NSAID and a systemic corticosteroid can injure the gastroduodenal mucosa, and using them together raises the likelihood of peptic ulceration and gastrointestinal bleeding. Celecoxib carries a lower GI risk than non-selective NSAIDs, but the risk is still increased with a corticosteroid.
What this interaction means in plain words
Celecoxib and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Deflazacort belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects on gastric mucosal integrity: NSAID prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest duration and consider gastroprotection with a proton pump inhibitor in patients at higher GI risk. Counsel patients to report black stools, vomiting blood or persistent abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Celecoxib with Deflazacort?
MediHelp rates the interaction as moderate. Celecoxib and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both an NSAID and a systemic corticosteroid can injure the gastroduodenal mucosa, and using them together raises the likelihood of peptic ulceration and gastrointestinal bleeding. Celecoxib carries a lower GI risk than non-selective NSAIDs, but the risk is still increased with a corticosteroid.
How serious is the interaction between Celecoxib and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider gastroprotection with a proton pump inhibitor in patients at higher GI risk. Counsel patients to report black stools, vomiting blood or persistent abdominal pain.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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