Drug interactions
Celecoxib + Dobutamine
Severity: Minor
Celecoxib and Dobutamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine tends to lower serum potassium by beta-2 mediated intracellular shift, whereas NSAIDs can cause potassium retention through reduced renal prostaglandin and renin effects. These effects mostly oppose one another and no clinically significant interaction is established.
What this interaction means in plain words
Celecoxib and Dobutamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Dobutamine belongs to Cardiovascular.
Why it happens
Opposing effects on potassium homeostasis; no clinically established interaction mechanism.
What to do
No specific action beyond routine monitoring of serum potassium and renal function in acutely ill patients receiving dobutamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Celecoxib with Dobutamine?
MediHelp rates the interaction as minor. Celecoxib and Dobutamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dobutamine tends to lower serum potassium by beta-2 mediated intracellular shift, whereas NSAIDs can cause potassium retention through reduced renal prostaglandin and renin effects. These effects mostly oppose one another and no clinically significant interaction is established.
How serious is the interaction between Celecoxib and Dobutamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond routine monitoring of serum potassium and renal function in acutely ill patients receiving dobutamine.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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