Drug interactions
Celecoxib + Drospirenone
Severity: Moderate
Celecoxib and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, and NSAIDs can add to this by reducing aldosterone and renal function. Clinically significant hyperkalemia is uncommon in healthy women but possible with renal impairment.
What this interaction means in plain words
Celecoxib and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention through aldosterone antagonism (drospirenone) and NSAID-induced reduction in renin-aldosterone activity and renal perfusion.
What to do
Check serum potassium during the first cycle of concurrent chronic use in patients at risk. Avoid in renal impairment or with other potassium-raising drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Celecoxib with Drospirenone?
MediHelp rates the interaction as moderate. Celecoxib and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, and NSAIDs can add to this by reducing aldosterone and renal function. Clinically significant hyperkalemia is uncommon in healthy women but possible with renal impairment.
How serious is the interaction between Celecoxib and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of concurrent chronic use in patients at risk. Avoid in renal impairment or with other potassium-raising drugs.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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