Drug interactions
Celecoxib + Efavirenz
Severity: Minor
Celecoxib and Efavirenz: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is cleared mainly by CYP2C9, and efavirenz has variable effects on CYP enzymes, mostly inducing CYP3A4 and having some inhibitory activity on CYP2C9 in vitro. The clinical effect on celecoxib levels is uncertain and probably small.
What this interaction means in plain words
Celecoxib and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Efavirenz belongs to Anti Virals.
Why it happens
Possible modulation of CYP2C9 metabolism of celecoxib by efavirenz; direction and magnitude are not well established.
What to do
No dose change is routinely needed; monitor for celecoxib adverse effects or reduced analgesic response if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Celecoxib with Efavirenz?
MediHelp rates the interaction as minor. Celecoxib and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib is cleared mainly by CYP2C9, and efavirenz has variable effects on CYP enzymes, mostly inducing CYP3A4 and having some inhibitory activity on CYP2C9 in vitro. The clinical effect on celecoxib levels is uncertain and probably small.
How serious is the interaction between Celecoxib and Efavirenz?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for celecoxib adverse effects or reduced analgesic response if symptoms occur.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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