Drug interactions
Celecoxib + Enoxaparin
Severity: Moderate
Celecoxib and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination increases the risk of bleeding, particularly gastrointestinal bleeding and, with neuraxial procedures, spinal hematoma. NSAIDs add antiplatelet and mucosal effects to anticoagulation.
What this interaction means in plain words
Celecoxib and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Enoxaparin belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment from antithrombin-mediated anti-Xa activity plus NSAID platelet inhibition and mucosal injury.
What to do
Avoid unless needed and monitor for bleeding signs and hemoglobin. Prefer acetaminophen for analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Celecoxib with Enoxaparin?
MediHelp rates the interaction as moderate. Celecoxib and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination increases the risk of bleeding, particularly gastrointestinal bleeding and, with neuraxial procedures, spinal hematoma. NSAIDs add antiplatelet and mucosal effects to anticoagulation.
How serious is the interaction between Celecoxib and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless needed and monitor for bleeding signs and hemoglobin. Prefer acetaminophen for analgesia.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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