Drug interactions
Celecoxib + Epoprostenol
Severity: Moderate
Celecoxib and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation and may increase bleeding risk with other agents affecting hemostasis. Celecoxib has little direct platelet effect but adds GI mucosal injury risk.
What this interaction means in plain words
Celecoxib and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Epoprostenol belongs to Genitourinary.
Why it happens
Additive pharmacodynamic effect on hemostasis: prostacyclin-mediated platelet inhibition plus NSAID mucosal injury.
What to do
Monitor for bleeding signs and hemoglobin during co-use. Avoid in patients with active GI bleeding or ulcer history where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Celecoxib with Epoprostenol?
MediHelp rates the interaction as moderate. Celecoxib and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation and may increase bleeding risk with other agents affecting hemostasis. Celecoxib has little direct platelet effect but adds GI mucosal injury risk.
How serious is the interaction between Celecoxib and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and hemoglobin during co-use. Avoid in patients with active GI bleeding or ulcer history where possible.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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