Drug interactions
Celecoxib + Eprosartan
Severity: Moderate
Celecoxib and Eprosartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of angiotensin receptor blockers and, together, they increase the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients. The risk is highest when diuretics are also used.
What this interaction means in plain words
Celecoxib and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Eprosartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins combined with angiotensin II receptor blockade reduces glomerular filtration and promotes potassium retention.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing therapy. Use the lowest effective celecoxib dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Frequently asked questions
Can I take Celecoxib with Eprosartan?
MediHelp rates the interaction as moderate. Celecoxib and Eprosartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of angiotensin receptor blockers and, together, they increase the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients. The risk is highest when diuretics are also used.
How serious is the interaction between Celecoxib and Eprosartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing therapy. Use the lowest effective celecoxib dose for the shortest time.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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