Drug interactions
Celecoxib + Fludrocortisone
Severity: Moderate
Celecoxib and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of gastrointestinal ulceration and bleeding, although fludrocortisone is used at low doses with limited glucocorticoid effect. Fludrocortisone and NSAIDs may also both contribute to fluid retention and raised blood pressure.
What this interaction means in plain words
Celecoxib and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Fludrocortisone belongs to Endocrine.
Why it happens
Additive gastric mucosal injury and additive sodium and fluid retention.
What to do
Monitor blood pressure, edema and electrolytes, and counsel on GI bleeding symptoms. Consider gastroprotection if other GI risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Celecoxib with Fludrocortisone?
MediHelp rates the interaction as moderate. Celecoxib and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of gastrointestinal ulceration and bleeding, although fludrocortisone is used at low doses with limited glucocorticoid effect. Fludrocortisone and NSAIDs may also both contribute to fluid retention and raised blood pressure.
How serious is the interaction between Celecoxib and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and electrolytes, and counsel on GI bleeding symptoms. Consider gastroprotection if other GI risk factors exist.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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