Drug interactions
Celecoxib + Gliclazide
Severity: Moderate
Celecoxib and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib inhibits CYP2C9, which is the main enzyme that metabolizes gliclazide, so exposure to the sulfonylurea may rise modestly. The result may be enhanced glucose lowering and hypoglycemia, although clinical reports are limited.
What this interaction means in plain words
Celecoxib and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Gliclazide belongs to Endocrine.
Why it happens
Celecoxib is a weak CYP2C9 inhibitor and may reduce gliclazide clearance.
What to do
Monitor blood glucose when celecoxib is started or stopped. Reduce the gliclazide dose if hypoglycemia appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Gliclazide?
MediHelp rates the interaction as moderate. Celecoxib and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib inhibits CYP2C9, which is the main enzyme that metabolizes gliclazide, so exposure to the sulfonylurea may rise modestly. The result may be enhanced glucose lowering and hypoglycemia, although clinical reports are limited.
How serious is the interaction between Celecoxib and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when celecoxib is started or stopped. Reduce the gliclazide dose if hypoglycemia appears.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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