Drug interactions
Celecoxib + Glipizide-metformin
Severity: Moderate
Celecoxib and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib inhibits CYP2C9 and may raise glipizide exposure, which can increase the risk of hypoglycemia. NSAID-related renal effects may also affect metformin clearance.
What this interaction means in plain words
Celecoxib and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible CYP2C9 inhibition reducing glipizide clearance, and reduced renal function from prostaglandin inhibition.
What to do
Monitor blood glucose and renal function, and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Glipizide-metformin?
MediHelp rates the interaction as moderate. Celecoxib and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib inhibits CYP2C9 and may raise glipizide exposure, which can increase the risk of hypoglycemia. NSAID-related renal effects may also affect metformin clearance.
How serious is the interaction between Celecoxib and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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