Drug interactions
Celecoxib + Glyburide-metformin
Severity: Minor
Celecoxib and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is metabolized by CYP2C9 and may modestly raise glyburide exposure, with rare hypoglycemia reported. NSAIDs may also affect renal function and hence metformin handling.
What this interaction means in plain words
Celecoxib and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible competition for CYP2C9 metabolism, plus NSAID effects on renal function.
What to do
Monitor blood glucose when celecoxib is started and check renal function in at-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Glyburide-metformin?
MediHelp rates the interaction as minor. Celecoxib and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib is metabolized by CYP2C9 and may modestly raise glyburide exposure, with rare hypoglycemia reported. NSAIDs may also affect renal function and hence metformin handling.
How serious is the interaction between Celecoxib and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when celecoxib is started and check renal function in at-risk patients.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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