Drug interactions
Celecoxib + Hydralazine
Severity: Moderate
Celecoxib and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as celecoxib can blunt the blood pressure lowering effect of vasodilators including hydralazine. They also promote sodium and fluid retention, which can further reduce antihypertensive control.
What this interaction means in plain words
Celecoxib and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Hydralazine belongs to Cardiovascular.
Why it happens
Inhibition of renal and vascular prostaglandin synthesis by celecoxib causes sodium and water retention and opposes vasodilation.
What to do
Monitor blood pressure and signs of fluid retention when celecoxib is started, changed or stopped. Adjust the antihypertensive regimen if control is lost, and use the lowest effective celecoxib dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Celecoxib with Hydralazine?
MediHelp rates the interaction as moderate. Celecoxib and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as celecoxib can blunt the blood pressure lowering effect of vasodilators including hydralazine. They also promote sodium and fluid retention, which can further reduce antihypertensive control.
How serious is the interaction between Celecoxib and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and signs of fluid retention when celecoxib is started, changed or stopped. Adjust the antihypertensive regimen if control is lost, and use the lowest effective celecoxib dose for the shortest time.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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