Drug interactions
Celecoxib + Hydrochlorothiazide-telmisartan
Severity: Moderate
Celecoxib and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of ARBs and diuretics and, with volume depletion, raise the risk of acute kidney injury (the so-called triple whammy). Hyperkalemia may also occur.
What this interaction means in plain words
Celecoxib and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion while ARB and diuretic therapy impair glomerular autoregulation.
What to do
Use the lowest effective NSAID dose for the shortest time, ensure hydration, and monitor blood pressure, creatinine and potassium; avoid in elderly or volume-depleted patients when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Celecoxib and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of ARBs and diuretics and, with volume depletion, raise the risk of acute kidney injury (the so-called triple whammy). Hyperkalemia may also occur.
How serious is the interaction between Celecoxib and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, ensure hydration, and monitor blood pressure, creatinine and potassium; avoid in elderly or volume-depleted patients when possible.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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