Drug interactions
Celecoxib + Ibrutinib
Severity: Moderate
Celecoxib and Ibrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and carries a bleeding risk, and celecoxib adds to GI mucosal injury and has mild antiplatelet effects. Together they may increase the risk of clinically significant bleeding, especially in the GI tract.
What this interaction means in plain words
Celecoxib and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Ibrutinib belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on haemostasis: BTK inhibition of platelet function plus NSAID-related mucosal damage.
What to do
Monitor for signs of bleeding and check blood counts periodically. Consider acetaminophen or another alternative where possible, and review any added antithrombotic therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Celecoxib with Ibrutinib?
MediHelp rates the interaction as moderate. Celecoxib and Ibrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and carries a bleeding risk, and celecoxib adds to GI mucosal injury and has mild antiplatelet effects. Together they may increase the risk of clinically significant bleeding, especially in the GI tract.
How serious is the interaction between Celecoxib and Ibrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check blood counts periodically. Consider acetaminophen or another alternative where possible, and review any added antithrombotic therapy.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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