Drug interactions
Celecoxib + Ivosidenib
Severity: Moderate
Celecoxib and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces several CYP enzymes, and labeling flags CYP2C9 substrates as potentially affected. Celecoxib exposure may fall, which could reduce its analgesic or anti-inflammatory effect.
What this interaction means in plain words
Celecoxib and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP2C9 and other enzymes, increasing celecoxib clearance.
What to do
Monitor for loss of celecoxib efficacy and increase the dose within the labeled range if needed. Consider an NSAID less dependent on CYP2C9 if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Celecoxib with Ivosidenib?
MediHelp rates the interaction as moderate. Celecoxib and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces several CYP enzymes, and labeling flags CYP2C9 substrates as potentially affected. Celecoxib exposure may fall, which could reduce its analgesic or anti-inflammatory effect.
How serious is the interaction between Celecoxib and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of celecoxib efficacy and increase the dose within the labeled range if needed. Consider an NSAID less dependent on CYP2C9 if control is inadequate.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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