Drug interactions
Celecoxib + Ketoconazole
Severity: Minor
Celecoxib and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise celecoxib concentrations by inhibiting its metabolism, increasing risk of dose-related NSAID toxicity. The effect is likely less than with fluconazole because celecoxib depends mainly on CYP2C9.
What this interaction means in plain words
Celecoxib and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4 and to a lesser extent CYP2C9, reducing celecoxib clearance.
What to do
No routine adjustment; monitor for GI, renal and fluid retention effects, particularly with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Celecoxib with Ketoconazole?
MediHelp rates the interaction as minor. Celecoxib and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may raise celecoxib concentrations by inhibiting its metabolism, increasing risk of dose-related NSAID toxicity. The effect is likely less than with fluconazole because celecoxib depends mainly on CYP2C9.
How serious is the interaction between Celecoxib and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for GI, renal and fluid retention effects, particularly with prolonged use.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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