Drug interactions
Celecoxib + Nateglinide
Severity: Minor
Celecoxib and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP2C9 substrates, so competition could slightly raise levels of either. Clinically relevant changes are not expected at usual doses, though NSAIDs may rarely alter glycemic control.
What this interaction means in plain words
Celecoxib and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Nateglinide belongs to Endocrine.
Why it happens
Competition for CYP2C9 metabolism.
What to do
No dose adjustment is usually needed; monitor blood glucose for hypoglycemia when celecoxib is added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Celecoxib with Nateglinide?
MediHelp rates the interaction as minor. Celecoxib and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are CYP2C9 substrates, so competition could slightly raise levels of either. Clinically relevant changes are not expected at usual doses, though NSAIDs may rarely alter glycemic control.
How serious is the interaction between Celecoxib and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor blood glucose for hypoglycemia when celecoxib is added.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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