Drug interactions
Celecoxib + Nilotinib
Severity: Minor
Celecoxib and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP2C9 in vitro and may modestly raise celecoxib exposure. Nilotinib also prolongs the QT interval, but celecoxib is not a known QT-prolonging drug, so the main concern is increased NSAID effects.
What this interaction means in plain words
Celecoxib and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP2C9, reducing celecoxib clearance.
What to do
No routine dose change; monitor for NSAID adverse effects and bleeding, especially if platelet counts are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Celecoxib with Nilotinib?
MediHelp rates the interaction as minor. Celecoxib and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP2C9 in vitro and may modestly raise celecoxib exposure. Nilotinib also prolongs the QT interval, but celecoxib is not a known QT-prolonging drug, so the main concern is increased NSAID effects.
How serious is the interaction between Celecoxib and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for NSAID adverse effects and bleeding, especially if platelet counts are low.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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