Drug interactions
Celecoxib + Nortriptyline
Severity: Moderate
Celecoxib and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may raise plasma concentrations of nortriptyline, which is cleared by CYP2D6. Higher levels may increase anticholinergic effects, sedation and cardiac conduction abnormalities.
What this interaction means in plain words
Celecoxib and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Nortriptyline belongs to Central Nervous System.
Why it happens
Celecoxib inhibits CYP2D6, reducing hydroxylation of nortriptyline.
What to do
Monitor for tricyclic adverse effects and consider plasma level or ECG monitoring in at-risk patients. Reduce the nortriptyline dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Celecoxib with Nortriptyline?
MediHelp rates the interaction as moderate. Celecoxib and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib may raise plasma concentrations of nortriptyline, which is cleared by CYP2D6. Higher levels may increase anticholinergic effects, sedation and cardiac conduction abnormalities.
How serious is the interaction between Celecoxib and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider plasma level or ECG monitoring in at-risk patients. Reduce the nortriptyline dose if toxicity appears.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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