Drug interactions
Celecoxib + Ofloxacin
Severity: Moderate
Celecoxib and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones. The risk is greatest in patients with epilepsy, prior seizures or other predisposing factors.
What this interaction means in plain words
Celecoxib and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones antagonize GABA-A receptors, and NSAIDs may potentiate this effect.
What to do
Avoid the combination in patients with seizure history or lowered seizure threshold; otherwise monitor for agitation, tremor or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Celecoxib with Ofloxacin?
MediHelp rates the interaction as moderate. Celecoxib and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent NSAIDs may increase the CNS stimulating and seizure-provoking potential of fluoroquinolones. The risk is greatest in patients with epilepsy, prior seizures or other predisposing factors.
How serious is the interaction between Celecoxib and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure history or lowered seizure threshold; otherwise monitor for agitation, tremor or seizures.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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