Drug interactions
Celecoxib + Paroxetine
Severity: Moderate
Celecoxib and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID increases the risk of gastrointestinal and other bleeding compared with either drug alone. Paroxetine also inhibits CYP2D6, but celecoxib is mainly a CYP2C9 substrate so that is not the main concern.
What this interaction means in plain words
Celecoxib and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin and impair platelet aggregation, while NSAIDs add gastric mucosal injury and platelet effects.
What to do
Monitor for signs of gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in older patients or those with prior ulcers. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Celecoxib with Paroxetine?
MediHelp rates the interaction as moderate. Celecoxib and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID increases the risk of gastrointestinal and other bleeding compared with either drug alone. Paroxetine also inhibits CYP2D6, but celecoxib is mainly a CYP2C9 substrate so that is not the main concern.
How serious is the interaction between Celecoxib and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in older patients or those with prior ulcers. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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