Drug interactions
Celecoxib + Primidone
Severity: Minor
Celecoxib and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, metabolized partly to phenobarbital, can induce enzymes and lower celecoxib exposure. This may reduce the anti-inflammatory or analgesic benefit.
What this interaction means in plain words
Celecoxib and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Primidone belongs to Central Nervous System.
Why it happens
Primidone and its phenobarbital metabolite induce hepatic CYP2C9, accelerating celecoxib metabolism.
What to do
Monitor symptom control and increase the celecoxib dose within labeled limits or use an alternative if response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Celecoxib with Primidone?
MediHelp rates the interaction as minor. Celecoxib and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone, metabolized partly to phenobarbital, can induce enzymes and lower celecoxib exposure. This may reduce the anti-inflammatory or analgesic benefit.
How serious is the interaction between Celecoxib and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and increase the celecoxib dose within labeled limits or use an alternative if response is poor.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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