Drug interactions
Celecoxib + Propranolol
Severity: Moderate
Celecoxib and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of beta-blockers over time. Celecoxib may slightly raise propranolol levels through weak CYP2D6 inhibition, though this is of minor importance since propranolol has several clearance pathways.
What this interaction means in plain words
Celecoxib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Propranolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and fluid retention, opposing beta-blocker effect, with minor CYP2D6 inhibition.
What to do
Monitor blood pressure during sustained NSAID use and adjust antihypertensive therapy as needed. Use the lowest effective celecoxib dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Celecoxib with Propranolol?
MediHelp rates the interaction as moderate. Celecoxib and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of beta-blockers over time. Celecoxib may slightly raise propranolol levels through weak CYP2D6 inhibition, though this is of minor importance since propranolol has several clearance pathways.
How serious is the interaction between Celecoxib and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during sustained NSAID use and adjust antihypertensive therapy as needed. Use the lowest effective celecoxib dose for the shortest duration.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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