Drug interactions
Celecoxib + Streptomycin
Severity: Minor
Celecoxib and Streptomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin-dependent perfusion and may lower clearance of aminoglycosides. This has mainly been described in preterm infants, where serum aminoglycoside concentrations can rise and increase the risk of nephrotoxicity and ototoxicity. In adults the effect is generally small.
What this interaction means in plain words
Celecoxib and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Streptomycin belongs to Anti Bacterial.
Why it happens
Reduced renal blood flow and glomerular filtration from prostaglandin inhibition decreases renal elimination of the aminoglycoside.
What to do
In neonates and in patients with renal impairment, monitor streptomycin serum levels and serum creatinine. No routine change is needed in adults with normal renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Celecoxib with Streptomycin?
MediHelp rates the interaction as minor. Celecoxib and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs reduce renal prostaglandin-dependent perfusion and may lower clearance of aminoglycosides. This has mainly been described in preterm infants, where serum aminoglycoside concentrations can rise and increase the risk of nephrotoxicity and ototoxicity. In adults the effect is generally small.
How serious is the interaction between Celecoxib and Streptomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In neonates and in patients with renal impairment, monitor streptomycin serum levels and serum creatinine. No routine change is needed in adults with normal renal function.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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