Drug interactions
Celecoxib + Tamoxifen
Severity: Minor
Celecoxib and Tamoxifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a weak CYP2D6 inhibitor and could theoretically reduce formation of endoxifen from tamoxifen. A clinically important loss of tamoxifen efficacy has not been demonstrated.
What this interaction means in plain words
Celecoxib and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Tamoxifen belongs to Endocrine.
Why it happens
Weak CYP2D6 inhibition by celecoxib may slightly reduce conversion of tamoxifen to endoxifen.
What to do
No change is needed routinely; avoid adding strong CYP2D6 inhibitors as a more important concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Celecoxib with Tamoxifen?
MediHelp rates the interaction as minor. Celecoxib and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib is a weak CYP2D6 inhibitor and could theoretically reduce formation of endoxifen from tamoxifen. A clinically important loss of tamoxifen efficacy has not been demonstrated.
How serious is the interaction between Celecoxib and Tamoxifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed routinely; avoid adding strong CYP2D6 inhibitors as a more important concern.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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